Direct Comparison: Methotrexate and Cyclosporine
If you’ve ever had to use drugs to treat eczema, you’ve wanted it to be the best, most effective drug available. But what is the best eczema drug? We want to know that we’re making the best possible choice for ourselves or for our children.
Up until now, there has never been a direct comparison of Atopic Dermatitis (eczema) drugs. However, the first head-to-head trial has taken place between two drugs: Methotrexate and Cyclosporine.
How do each of the drugs weigh in?
In a nutshell, Methotrexate was found safer but less effective than Cyclosporine for treating Atopic Dermatitis (eczema).
The juxtaposition of effectiveness against safety does not necessarily make the decision any more clear-cut. In the study, tests were carried out in randomized, controlled, single-blind, non-inferiority trials of Methotrexate and Cyclosporine in adults with Atopic Dermatitis (eczema).
Cyclosporine was found to be about five times more effective in terms of SCORAD 50. However, there were more adverse side effects.
The important points to note:
- Methotrexate has a better safety profile but is less effective than cyclosporine in clearing moderate to severe Atopic Dermatitis.
- 42% of the Cyclosporine group achieved SCORAD 50 at week 8.
- Only 8% of the Methotrexate group achieved SCORAD 50 at week 8.
Based on the findings of the study, Dr. Goujon-Henry from the Clinical Research Unit in Immunology at Lyon-Sud Hospital in Lyon, France, recommended the following:
“Dermatologists should consider treating Atopic Dermatitis patients with a relatively high dose of methotrexate, such as 15 mg weekly, or first stabilize flaring patients with cyclosporine and then switch them to methotrexate for long-term disease control…Taken together, the findings support using methotrexate as first-line therapy for moderate to severe atopic dermatitis, but patients need to expect a slower treatment response in exchange for the better safety profile.”
Also, consider wet wrap therapy as a way to control severe Atopic Dermatitis (eczema). Wet wrap therapy is a proven treatment for Atopic Dermatitis (eczema) with no side effects and research has shown an average reduction of symptoms by 70% in just 5 easy treatments and it also reduces the need for drugs. For more information on wet wrap therapy visit this article at http://www.adrescuewear.com/blog/wet-wraps-for-eczema-are-a-great-relief-without-side-effects/