A new topical treatment for children and adults suffering with mild to moderate atopic dermatitis (AD) or eczema was approved by the Food and Drug Administration on December 14th, 2016. If you or your child suffers with eczema you may be aware there haven't been many new drug treatment options in the last 10 years. The main course of treatment is usually a prescribed steroid cream. At AD RescueWear, we hear from frustrated parents who have had little relief with the usual course of treatment. So, the announcement of the FDA approved drug Eucrisa is very exciting for many.
But what is this new topical treatment and how does it work? It is not a steroid or a topical calcineurin inhibitor such as the prescription drugs Protopic or Eilidel. Eucrisa is a topical anti-inflammatory phosphodiesterase 4 (PDE-4) inhibitor. Its specific mechanism of treating eczema is not completely known, but it is believed to work by inhibiting PDE-4 in target cells. This reduces the production of pro-inflammatory cytokines thought to cause the signs and symptoms of eczema. Cytokines are proteins produced by our cells that aid cell to cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection and trauma.
The clinical trials have shown that applying Eucrisa (crisaborole) twice daily is effective at decreasing inflammation and is well-tolerated with long term use. Most participants noticed clear or almost clear skin after 28 days of use. Serious side effects listed include hypersensitivity reactions. Eucrisa should not be used in patients who have had a hypersensitivity reaction to Eucrisa’s active ingredient, crisaborole. The most common side effect of using Eucrisa is pain when applied, including burning or stinging. It is available by prescription for people ages 2 years and older.
What do you think of this new development and will you ask your physician for a prescription? Keep in mind that AD Rescue Wear Eczema Clothing is also available by prescription by your physician.
Please let us know, we would love to hear and share with our community. Best wishes from AD RescueWear for healthy skin this winter and new year.